MK-677 30mg/ml 30ml

(17 customer reviews)


MK-677 SARMS (Ibutamoren, MK-0677, L-163,191) is an orally administered growth hormone secretagogue. A secretagogue is a substance that promotes secretion. By this standard, MK-677 can be compared to peptides such as GHRP-6 or Ipamorelin. The main advantage is that it can be administered orally and does not require injections nor does it have the side effects that GHRP-6 does. MK-677 was developed with the intention of combating conditions such as muscle atrophy, osteoporosis, and obesity.*


***Shake well before each use.***

***Intended for research purposes only.***


Ibutamoren (INN) (developmental code names MK-677 SARMs, MK-0677, L-163,191) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor 1 (IGF-1), but without affecting cortisol levels. MK677 has shown to sustain activation of GH-IGF-1 Axis and increase in lean body mass but no change in total fat mass or visceral fat. It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly.

MK-677 SARMS was shown to increase IGF-1 levels by between 39-89% in several studies. Here are some IGF-1 benefits:

Increased Fat Oxidation (fat loss)
Increased Muscle gains (lean mass)
Tightening up loose skin
Healing old injuries
Healing Bones, Tendons and Ligaments
Given the fact that is does not compete with GH levels from exogenously administered HGH, it can be used in high cycles.It is important to note that Growth hormone pulse intensity can be increased through 4 possible mechanisms and MK-677 works through all four.

It increases GHRH (growth hormone releasing hormone) release.
It amplifies GHRH signaling.
It reduces somatostatin release which is desirable because somatostatin turns off GH release.
It inhibits somatostatin receptor signaling.
MK-677 SARMS has been associated with improved sleep, better complexion, increased strength and energy, increased nitrogen retention and a better sense of well-being. Some studies showed that MK-677 boosts immune system response. MK-677 has a half-life of 24 hours.

*All prices in Canadian dollars. The information presented here is intended for educational / informational purposes only

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