SR-9009 SARMS also known as Stenabolic is a research drug that was developed by Professor Thomas Burris of the Scripps Research Institute as an agonist of Rev-ErbA (i.e., increases the constitutive repression of genes regulated by Rev-ErbA) with a half-maximum inhibitory concentration (IC50) = 670 nM for Rev-ErbAα and IC50 = 800 nM for Rev-ErbAβ.
Activation of Rev-erb-α by in mice SR9009 SARMS increases exercise capacity in mice by increasing mitochondria in skeletal muscle.
In spite of being associated with SARMS, Stenabolic (SR-9009) is in fact a Rev-ErbA ligand. It means SR binds to this protein and makes it more active. As a result, the user will experience a lot of positive effects, such as increased fat loss, enhanced endurance, and many other health benefits.
As mentioned beforehand, SR9009 is a synthetic Rev-Erb ligand, which is taken orally. This is a very unique compound. By stimulating the Rev-Erb protein, SR-9009 SARMS has the ability to greatly influence a lot of regulatory mechanisms in the human body. For instance, it can affect the circadian rhythms, lipid and glucose metabolism, fat-storing cells, as well as macrophages. Hence, Stenabolic will allow the user to lose fat and drastically increase endurance, both of which are very desirable effects for an athlete.
Studies carried out with SR-9009 SARMS have shown that it will decrease:
Total cholesterol by 47%
Plasma insulin level by 35%
Plasma non-esterified fatty acids by 23%
Plasma glucose by 19%
Plasma triglycerides by 12%
SR-9009 SARMS will also decrease proinflammatory cytokine IL-6 by 72%, which is clearly beneficial for reducing inflammation.
SR-9009 SARMS binds to a protein called Rev-erbA. This is significant since this protein influences fat and sugar burning in the liver, production of fat cells, and the body’s inflammatory responses.SR-9009 does not act like a fat burner, thyroid accelerator, or appetite suppressant. SR-9009 can affect the circadian rhythms, lipid and glucose metabolism, fat-storing cells, as well as macrophages. Due to increases in number of macrophages, defective mitochondria are removed from the muscles and replaced with new ones.SR-9009 has a half-life of around 12 hours.
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